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Li Gong

Mixed Results for Genotype-guided Warfarin Dosing - Update

Update: New perspective piece from the New England Journal of Medicine The December 12 issue of the New England Journal of Medicine includes a perspective piece discussing the recent trial results on coumarin dosing. This article, Pharmacogenetics and Coumarin Dosing — Recalibrating Expectations, by Zineh et al from the Food and

Mixed Results for Genotype-guided Warfarin Dosing

Update (12/17/2013):New perspective piece from the New England Journal of Medicine The December 12 issue of the New England Journal of Medicine includes a perspective piece discussing the recent trial results on coumarin dosing. This article, Pharmacogenetics and Coumarin Dosing — Recalibrating Expectations, by Zineh et al from

Viva La Evidence

We came across this brilliant music video “Viva La Evidence” by Dr. James McCormack. It’s a parody of Coldplay's Viva La Vida and the lyrics cover many important topics of evidence based medicine, its history, principles and aims. What a fun way to explain the hierarchy of

CPIC publishes guidelines for IFNL3 (IL28B) and peginterferon alpha based regimens

Guidelines regarding the use of IFNL3 (formerly known as IL28B) genotypes in peginterferon alpha based therapies have been accepted for publication in the Clinical Pharmacology and Therapeutics by the Clinical Pharmacogenetics Implementation Consortium (CPIC). Hepatitis C virus (HCV) infection affects more than 150 million people worldwide and is one of

CYP2C8 VIP published in PG&G

CYP2C8 is a member of the cytochrome P450 family of drug metabolizing enzymes. It plays a major role in the metabolism of many commonly used drugs. Several CYP2C8 SNPs have been associated with variability in metabolism, disposition and response for drugs such as repaglinide, rosiglitazone, pioglitazone, paclitaxel, bisphosphonates, amiodarone and

New VIP Summary for CYP2C8

A new VIP summary is available for CYP2C8, a member of the cytochrome P450 family of drug metabolizing enzymes. CYP2C8 accounts for 7% of CYP content in the liver, and is expressed to a lesser extent in the kidney, adrenal gland, mammary gland, brain, ovary, uterus, and duodenum. CYP2C8 plays

The PGRN Translational Pharmacogenetics Program (TPP) publishes paper on overcoming challenges of real-world implementation

The Translational Pharmacogenetics Program (TPP) is a Pharmacogenomics Research Network (PGRN)-led initiative with the goal to identify barriers and develop real-world solutions to implement evidence-based pharmacogenetic tests in diverse health care settings. The participating sites include 6 implementation institutions (Universityof Maryland, University of Florida, St. Jude Children's

Implementing pharmacogenetics: more than one gene at a time

It has been well recognized that drug response is complex and determined by not only one gene, but rather by the interplay of multiple gene products. However, studies of combined impact of more than one gene are scarce, limiting the potential for making strong dosing recommendations based on multiple genes.

New pathway: Vemurafenib Pathway, Pharmacodynamics

We have added a new pathway: Vemurafenib PD pathway to our pathway collections. Vemurafenib (marketed as ZELBORAF) is an oral BRAF inhibitor used to treat late-stage melanoma. It specifically targets the mutant BRAF protein (V600E isoform) that is found in approximately half of all cases of melanoma. Vemurafenib is a

New pathways on PharmGKB: Sorafenib PK and PD

We have added two new pathways: Sorafenib PK and PD pathways to our pathway collections. Sorafenib (Nexavar, BAY 43-9006) is a cancer drug used to treat advanced renal cell carcinoma and unresectable hepatocellular carcinoma. It blocks tumor cell proliferation and angiogenesis by targeting various types of serine/threonine and receptor