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Latest — Jan 16, 2025

UPDATE: CHANGE IN DATE for ClinPGx/CPIC/PGRN meeting

The ClinPGx/CPIC/PGRN meeting will now start on Wednesday, September 10, 2025 and end on Friday afternoon, September 12, 2025 in Missoula, Montana. (Change of start date due to airport closure for repaving of their one runway which happens every 20 years in Missoula, Montana.) We anticipate holding a

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ClinGen’s Pharmacogenomics Interpretation Committee Publishes Paper in Clinical Chemistry

We are pleased to announce that ClinGen’s Pharmacogenomics Interpretation Committee (PGxIC, previously known as the Pharmacogenomics Working Group (PGxWG)) has published its first paper in the journal Clinical Chemistry! The group recently updated its name to better reflect the scope and focus of its activities in advancing pharmacogenomic interpretation

Updated PharmVar CYP1A2 Nomenclature

From Andrea Gaedigk and Pablo Zubiaur on behalf of the CYP1A2 PharmVar expert panel PharmVar now provides expert panel curated nomenclature for CYP1A2. Before Dec 16, 2024, PharmVar displayed the legacy content of the former Human Cytochrome P450 Nomenclature Database which was updated for the last time in 2007. This

FDA and AACR to host DPYD testing workshop in January 2025

The U.S. Food and Drug Administration (FDA) Oncology Center of Excellence and the American Association for Cancer Research (AACR) are hosting a one day workshop to discuss DPYD testing. The purpose of this workshop is to provide an interdisciplinary forum to examine the existing information and evidence surrounding DPD

GBC Open Letter Campaign: Please join us in highlighting the critical importance of enhancing biodata resource sustainability

The Global Biodata Coalition (GBC) has just launched an open letter campaign to emphasize the essential role of biodata resources in advancing research and discovery, as well as the urgent need for sustainable funding to support the global life science data infrastructure. Please add your voice to this vital cause

AMP Survey on PGx Genotyping Recommendations

The Association for Molecular Pathology (AMP) Pharmacogenomics Working Group has launched a survey that is designed to understand the impact and evaluate the implementation of their series of recommendations on clinical PGx testing. The survey is designed to capture individual responses from molecular laboratory professionals currently performing, planning to perform,

Save the Date for ClinPGx/CPIC/PGRN 2025

The ClinPGx/CPIC 2025 Meeting will be held in collaboration with the PGRN in Missoula, Montana, September 8-11, 2025.

PharmVar Gene Focus on CYP4F2

PharmVar expert panel has reviewed and published a Gene Focus paper on CYP4F2 [PMID: 39135485]. The most well known drug pathway involving CYP4F2 is warfarin, where it is involved in the cycling of vitamin K. The CPIC guideline for warfarin and CYP4F2 gives details of the pharmacogenomic algorithms for warfarin

New PharmVar GeneFocus published for CYP2A6

PharmVar expert panel for CYP2A6 has published a review that presents allele nomenclature and includes a discussion on additional genes in the locus: CYP2A13 and CYP2A7 [PMID:39051767]. CYP2A6 metabolizes a variety of drugs including nicotine, efavirenz, tegafur, letrozole, and metronidazole for which PharmGKB has interactive pharmacokinetics pathways available. (There

ClinPGx 2024 meeting presentation videos and slides now available!

The ClinPGx 2024 meeting focused on Knowledge, Implementation and Education was held June 20-21, 2024 at the University of Pennsylvania. This meeting, held in collaboration with CPIC, PharmGKB, PharmCAT, PharmVar and the Penn Institute for Biomedical Informatics, provided educational content to cover PGx implementation including knowledgebases, implementation strategy, informatics, use