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PharmGKB Staff

Effect of a genetic variant associated with Multiple Sclerosis mirrors response to anti-TNF therapy

Though anti-TNF therapy can be effective in the treatment of many auto-immune diseases including Rheumatoid Arthritis (RA), drugs that block TNF can promote or exacerbate Multiple Sclerosis (MS). A genetic variant (rs1800693) within the TNFRSF1A gene has been identified in multiple GWAS as being associated with MS but not associated

Genetic contribution of response to opioids

Opioids are commonly prescribed for pain relief, yet many individuals suffer adverse side effects such as nausea, dizziness and sedation. A study published in this month's Anesthesiology set out to establish the relative contribution of genetic and environmental factors in opioid response. 114 monozygotic and dizygotic twin pairs

Helix Group & PharmGKB Retreat

Much fun and team-building was had at the Stanford Helix Group & PharmGKB retreat in San Diego last week - including sea kayaking, insightful talks and a lively discussion with guest speaker Philip Bourne.

New haplotypes available on PharmGKB

Haplotypes for the UGT1A3, CYP2F1 and CHRNA5 genes are now available on www.pharmgkb.org View a list of all the genes with haplotypes available on PharmGKB.

CYP2C19 and clopidogrel therapy CPIC guideline endorsed by the ASHP

The American Society of Health-System Pharmacists (ASHP) has endorsed the CPIC guidelines for CYP2C19 genotype and clopidogrel therapy, published in Clinical Pharmacology and Therapeutics. In their report, they highlight that the guidelines address an important need for information on the clinical application of pharmacogenomic testing and appreciate that the recommendations

CYP2C8 haplotype table available

The most recent addition to the PharmGKB set of haplotype tables is for CYP2C8 (cytochrome P450, family 2, subfamily C, polypeptide 8 ). The main source for this table was the The Human Cytochrome P450 (CYP) Allele Nomenclature Database . The PharmGKB haplotype tables, each located on a tab of the relevant

SFSU Personalized Medicine Conference - the role of epigenetics

See you at the San Francisco State University Personalized Medicine Conference 5.0, which this year focuses on epigenetics with speakers from academia and industry. Thursday 24th May, 8:00am-7:30pm South San Francisco Conference Center

Bay Area Biotechnology Symposium - Pharmaceuticals for the Future

UCSF School of Pharmacy, Industry Outreach Program is hosting a Bay Area Biotechnology Symposium tomorrow discussing the problems and solutions of developing Pharmaceuticals for the Future. It is open to all audiences...see you there! Saturday 19th May 2012 9:00am to 1:00pm Genentech Hall, Byers Auditorium, UCSF Mission

NAT1 Haplotype table now available on PharmGKB

Haplotype tables are useful recent additions to PharmGKB, and the latest addition to the set is for NAT1 (N-acetyltransferase 1). The main source for this table was the University of Louisville School of Medicine Arylamine N-acetyltransferase Gene Nomenclature Committee website. The PharmGKB haplotype tables, located on tabs of Gene pages,

Understanding the effect of protein structure variation on drug response

Understanding how genetic variants translate into variability in phenotype is important in the field of personalized medicine. In this review, Lahti et al discuss combining knowledge of pharmacogenetics, the impact of genetic variation on protein structure, and the molecular mechanisms of how a drug works (pharmacodynamics), to provide a greater