CPIC Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update

The 2022 CPIC Guideline update for CYP2C19 Genotype and Clopidogrel Therapy is now published in Clinical Pharmacology and Therapeutics. The article can be accessed on the PharmGKB page for clopidogrel and on the CPIC website.

Clopidogrel is a commonly prescribed antiplatelet prodrug and CYP2C19 is a significant contributor in the two-step conversion of clopidogrel to its active metabolite. Response to clopidogrel varies widely and CYP2C19 intermediate and poor metabolizers experience reduced platelet inhibition and increased risk for major adverse cardiac and cerebrovascular events.

The 2022 update includes expanded indications for CYP2C19 genotype-guided antiplatelet therapy, increased strength of recommendation for CYP2C19 intermediate metabolizers, and evidence from an expanded literature review.

For therapeutic recommendations and further details, please refer to the Guideline for Clopidogrel and CYP2C19.