CPIC Guideline Update for Allopurinol and HLA-B*58:01 Published

The 2015 update of CPIC guideline for allopurinol and HLA-B*58:01 has been published in Clinical Pharmacology and Therapeutics. CPIC extensively reviewed the recent literature and concluded that the dosing recommendations provided in the 2013 CPIC guideline have not changed.

The 2015 update includes the following additions:

  • Updated evidence linking HLA-B*58:01 to phenotype (Supplemental Table S3).
  • Added figures depicting clinical implementation workflow for EHR and Point of Care Clinical Decision Support (Supplemental Figures S1 and S2)

View the interactive CPIC allopurinol dosing guideline based on HLA-B*58:01, with the available full update and original published guidelines.

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