CPIC guidelines for TPMT and Thiopurine dosing: Update 2013

The 2013 update of the CPIC guidelines for TPMT and Thiopurine dosing is now available online, as an accepted article preview. CPIC genotype-based dosing guidelines are reviewed and updated every two years in order to be clinically current - this is the first update to be released.

After an extensive literature review, CPIC concluded that there is no new evidence that would result in changes to the original guidelines, published in 2011 and available to read or download from PharmGKB.

Read the 2013 update:

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for thiopurine methyltransferase (TPMT) genotype and thiopurine dosing: 2013 update Mary V. Relling, Eric E. Gardner, William J. Sandborn, Kjeld Schmiegelow, Ching-Hon Pui, Sook Wah Yee, Charles M. Stein, Michelle Carrillo, William E. Evans, J. Kevin Hicks, Matthias Schwab and Teri E. Klein.
Clin Pharmacol Ther  doi:10.1038/clpt.2013.4; accepted article preview online January 17, 2013.

View the CPIC gene-drug pairs table with the current status of guidelines and updates.