CPIC Publishes Their Guideline Development Process

In Current Drug Metabolism, the Clinical Pharmacogenetics Implementation Consortium (CPIC) has defined the standardized operating procedures undertaken for each guideline written. Outlined in the publication is how gene-drug relationships are initially assessed for a potential guideline, how a writing committee with experts in the subject is established, the gathering and grading of evidence linking a genotype to drug response and the development of a therapeutic recommendation. The standard format of a CPIC guideline paper and the process of evaluation by the CPIC steering committee is also defined.

In the article, CPIC guidelines are compared and evaluated against the Institute Of Medicine's (IOM's) standards for developing trustworthy clinical practice guidelines, from establishing transparency to updating.

All CPIC guidelines and updates are posted on PharmGKB in an interactive format. The CPIC Informatics working group is developing methods to enable integration and implementation of CPIC guidelines into electronic medical systems.  

> View all CPIC dosing guidelines
> View the list of CPIC guideline gene-drug pairs that have been published or are in progress.
> View all CPIC publications

Read the article:
Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process.
Kelly E. Caudle, Teri E. Klein, James M. Hoffman, Daniel J. Müller, Michelle Whirl-Carrillo, Li Gong, Ellen M. McDonagh, Katrin Sangkuhl, Caroline F. Thorn, Matthias Schwab, José A.G. Agúndez, Robert R. Freimuth, Vojtech Huser, Ming Ta Michael Lee, Otito F. Iwuchukwu, Kristine R. Crews, Stuart A. Scott, Mia Wadelius, Jesse J. Swen, Rachel F. Tyndale, C. Michael Stein, Dan Roden, Mary V. Relling, Marc S. Williams and Samuel G. Johnson.
Current Drug Metabolism (2014) Jan 30. [Epub ahead of print, PMID:24479687].

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