New must-test alleles for DPYD
The recently published article DPYD Genotyping Recommendations: A Joint Consensus Recommendation of the Association for Molecular Pathology, American College of Medical Genetics and Genomics, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, Pharmacogenomics Knowledgebase, and Pharmacogene Variation Consortium [PMID:39032821] gives a review of the Tier 1 and Tier 2 alleles to be tested for DPYD implementation.
![](https://blog.clinpgx.org/content/images/2024/07/Screenshot-2024-07-29-at-08.52.33.png)
For the fully linked table see https://www.pharmgkb.org/ampAllelesToTest
The AMP recommendations for this and all other must-test alleles are linked from several places in PharmGKB:
Homepage
![](https://blog.clinpgx.org/content/images/2024/07/Screenshot-2024-07-29-at-08.40.18.png)
Gene overview
![](https://blog.clinpgx.org/content/images/2024/07/Screenshot-2024-07-29-at-08.45.45.png)
Haplotype overview
![](https://blog.clinpgx.org/content/images/2024/07/Screenshot-2024-07-29-at-08.42.54.png)