New PharmGKB VIP Summary: SLC22A1 (OCT1)

Solute carrier family 22 (organic cation transporter), member 1 (SLC22A1, also called OCT1) is a polyspecific cationic transporter mediating the uptake of many organic cations from the blood into epithelial cells. It is predominantly expressed in the liver and plays a critical role in the hepatic uptake of many commonly used drugs.

Several SLC22A1 SNPs have functional consequences and have been associated with altered disposition and response for drugs such as metformin, imatinib, tropisetron, ondanesetron, morphine and tramadol. As a result, SLC22A1 is considered as an important pharmacogene.

For more information on this VIP gene and its important variants see the VIP tab for SLC22A1.

For all VIP gene summaries on pharmgkb, see here.