New PharmVar GeneFocus published for CYP2A6

PharmVar expert panel for CYP2A6 has published a review that presents allele nomenclature and includes a discussion on additional genes in the locus: CYP2A13 and CYP2A7 [PMID:39051767].

CYP2A6 metabolizes a variety of drugs including nicotine, efavirenz, tegafur, letrozole, and metronidazole for which PharmGKB has interactive pharmacokinetics pathways available. (There are 14 additional pathways that include CYP2A6). Read more about CYP2A6 PGx associations from the literature on PharmGKB.

The PharmVar CYP2A6 gene page shows the star allele nomenclature, and other important information such as legacy name(s) under which a particular allele was first published, SNPs defining the allele, allele evidence level, and references supporting allele definitions.

Other PharmVar GeneFocus summaries CYP2D6, CYP2C9, CYP2C19, CYP2B6, CYP3A5, and SLCO1B1.