New publication: NAT2 VIP Summary

The PharmGKB Very Important Pharmacogene (VIP) summary for NAT2 has been published in Pharmacogenetics & Genomics.

The review summarizes the important role NAT2 plays in the metabolism and detoxification of many therapeutic drugs, and why genetic variants within the NAT2 gene are associated with drug-induced toxicity as well as cancer. Associations between drug responses and important NAT2 variants are detailed, and possible reasons behind a lack of consistency for some associations are discussed.  

> View an interactive version of the NAT2 VIP summary on PharmGKB.

> Read the article:

PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.

McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE. Pharmacogenetics & Genomics. 2014 Jun 2. (Epub ahead of print)

NAT2 genetic variants have been linked to drug-induced hepatotoxicity

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