New VIP gene summary for CYP2E1

A new VIP summary is available for CYP2E1, a member of the cytochrome P450 family of drug metabolizing enzymes. CYP2E1 is constitutively expressed in the liver but makes up less than 1% of the total hepatic P450 isoforms [Article: 20100563]. It metabolizes relatively few prescription drugs (approximately 2%), however its important in the toxicity of acetaminophen, the antituberculosis drug isoniazid, and the probe drug and muscle relaxant chlorzoxazone [Article: 18695978]. Pathways for acetaminophen and isoniazid are in development and will be released soon ( NEW: Acetaminophen Pathway, Pharmacokinetics is released 1/16/2013).

For more information on this VIP gene and its variants see the VIP tab for CYP2E1

Subscribe to ClinPGx Blog

Don’t miss out on the latest issues. Sign up now to get access to the library of members-only issues.