PharmVar Gene Focus on CYP4F2

PharmVar expert panel has reviewed and published a Gene Focus paper on CYP4F2 [PMID: 39135485].

The most well known drug pathway involving CYP4F2 is warfarin, where it is involved in the cycling of vitamin K.

The CPIC guideline for warfarin and CYP4F2 gives details of the pharmacogenomic algorithms for warfarin dosing and involvement of rs2108622 C>T, which is the defining variant of CYP4F2*3 but is also found in CYP4F2*4. The Gene-specific Information tables have downloadable allele mappings, and other resources from CPIC. Allele frequencies from major biobanks such as All of Us and UK Biobank can also be viewed on each haplotype page by scrolling down (screen shot below).