pathway

We have added two new pathways: Sorafenib PK and PD pathways to our pathway collections. Sorafenib (Nexavar, BAY 43-9006) is a cancer drug used to treat advanced renal cell carcinoma and unresectable hepatocellular carcinoma.  It blocks tumor cell proliferation and angiogenesis by targeting various types of serine/threonine and receptor

Metformin is a first line therapy for type 2 diabetes, and is one of the most commonly prescribed drugs worldwide.   We have recently written a Metformin Pathways Summary that is published in Journal Pharmacogenetics and Genomics. Metformin effectively lowers both basal and postprandial plasma glucose. However, the glycemic response to

Tenofovir is an anti-HIV drug that works by inhibiting the replication of the HIV virus. Transporter genes encode proteins that are involved in the movement of the drug in and out of cells in the body, and the eventual elimination of the drug from the body. Clearance and elimination of