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Katrin Sangkuhl

Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics

We updated the Mycophenolic acid Pathway in collaboration with Kinjal Sanghavi and Dr. Vishal Lamba from the University of Minnesota.Mycophenolic Acid (MPA) is an immunosuppressive agent and is indicated as prophylactic agent in patients receiving allogeneic renal, cardiac or hepatic transplants. This PharmGKB pathway describes the steps and metabolites

Zidovudine Pathway Publication

Zidovudine (ZDV, also known as azidothymidine (AZT)) is an important drug used for treatment of HIV infection. Belonging to the family of nucleoside analog reverse transcriptase inhibitor (NRTI), it is structurally related to the endogenous nucleoside thymidine. ZDV is a prodrug and must be activated by phosphorylation to exert its

Curators' Favorite Papers

The current Curators' Favorite Papers highlight articles about the translation of pharmacogenomics into practice. The article by Johnson et al. describes the design of a customized pharmacogenetics genotyping array. This broad pharmacogenetics panel is built for the personalized medicine programs of the University of Florida and Stanford University [PMID:

Curators' Favorite Papers

Current Curators' Favorite Papers: The review by Alfirevic and Pirmohamed discusses genetic factors associated with drug-induced liver injury with a special focus on HLA gene variation [PMID: 22850601]. Parvez et al. reports that a common SNP on chromosome 4q25, which is associated with atrial fibrillation, modulates response to antiarrhythmic

Curators' Favorite Papers

The current Curators' Favorite Papers are about pharmacogenomics of antidepressant drugs. Narasimhan and Lohoff review recent findings on the pharmacogenetics of antidepressant drugs and discuss possible future clinical implementations [PMID: 22380000]. The study by de Klerk et al. investigates the association of ABCB1 variants with adverse effects of antidepressants

Curators' Favorite Papers

The current Curators' Favorite Papers are about rare variants, which are part of the genetic diversity within and among populations. Keinan and Clark explain how the recent explosive human population growth has resulted in an excess of rare genetic variants [PMID: 22582263]. The article by Nelson et al. focuses

Curators Favorite Papers

The current Curators Favorite Papers are about the pharmacogenetics of statins. The review by Postmus et al. discusses achievements, whole-genome analyses and future perspectives [PMID: 22594514]. Van der Baan et al. investigate the value of pharmacogenetic testing in predicting statin response using data from the REGRESS trail [PMID: 22547143]. The

Curators Favorite Papers

The current Curators Favorite Papers are selected around pharmacogenetics of smoking cessation and nicotine metabolism. The review by Gold & Lerman [PMID: 22290489] discusses evidence for the association of cholinergic and nicotine metabolism gene variations with smoking cessation and therapeutic response. The article by Binnington et al. [PMID: 22569203] studied