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PharmGKB Staff

Defining our lists of PGx information

With the increasing implementation of pharmacogenomics knowledge we are often asked "What is the difference between the CPIC gene list, VIP list and the Clinical Annotations list on PharmGKB?" Here we clarify their contents: VIP genes (purple layer of the PharmGKB Knowledge Pyramid) This is a list of

PGx Look Up Tables

The Translational Pharmacogenetics Project (TPP) is a PGRN-led initiative with the goal to operationalize the work of CPIC by translating widely accepted actionable pharmacogenetics discoveries into real-world clinical practice. TPP creates "look up" tables by gene which contain phenotype and clinical decision support system information based on haplotypes

New Haplotype features on PharmGKB

New features on the Haplotype tab (example: CYP2A6): * Details of the resources used to determine our curated haplotype maps and any important notes regarding the haplotypes are added by our curators. * Previously we only displayed dbSNP rsIDs within haplotypes - now you can view other genetic variants that currently have

PharmGKB Clinical Annotations Update and New Levels of Evidence

We have launched an update of our Clinical Annotations, assessing new evidence available for each gene variant - drug association. Each Clinical Annotation is written by a PharmGKB curator and assigned a level of evidence. We have recently revised our criteria to provide 6 levels of evidence, from the highest

The 1200 Patients Project

"The 1200 Patients Project" is a pharmacogenetics (PGx) implementation project established by a team at the University of Chicago who recruited 12 physicians to participate. The project is prospectively recruiting 1200 adults taking 1-6 prescription drugs, who are under the care of one of the participating physicians, and

Development of a Customized PGx Genotyping Array using key variants in PharmGKB

The University of Florida and Stanford University are undertaking a joint pharmacogenetics implementation project funded by the NIH, piloted first at Florida and replicated at Stanford. Initially, CYP2C19 genotype will be used to guide clopidogrel therapy, however a customized array of SNPs from 120 genes involved in drug response was

New sortable PGx Research tables on PharmGKB

Tables of our Variant Annotations found on the PGx Research tab (view on gene, drug, variant and haplotype pages) can now be sorted and filtered to allow you to see the most relevant information you want to see. example:If you want to see all variant annotations between the genetic

New features on the PharmGKB website

Check out the new features we have launched at www.pharmgkb.org * Information is now more readily available, including haplotypes listed in the PGx Research Tab on gene and drug pages, and sortable tables. * Our Clinical Annotations and Variant Annotations have their own page and a new look * Variant Annotations

Mining the pharmacogenomics literature

Briefings in Bioinformatics Special Issue: Current Progress in Bioinformatics 2012 contains an editorial by Russ Altman discussing the current status of bioinformatics research. Among the articles in this special issue is a review on the current status of techniques for mining of the pharmacogenomics literature and includes descriptions of studies

A message about RFA-HG-12-016

RFA-HG-12-016 "Clinically relevant genetic variants resource: a unified approach for identifying genetic variants for clinical use (U01)." The PharmGKB team is excited to see this RFA because clinical genomics has great potential to impact medicine. PharmGKB catalogs genetic variation of relevance to drug response (pharmacogenomics) and moves research