RIP Stephen Hawking
"However difficult life may seem, there is always something you can do and succeed at. It matters that you don't just give up." - Stephen Hawking
Rest in peace.
More issues
NIH Requests Input on Draft Strategic Plan for Data Science
The National Institutes of Health (NIH) is drafting a Strategic Plan for Data Science and is requesting feedback from the community. The amount of data in the biomedical field continues to grow exponentially, leading to "Big Data" and the increasing role of data science to process and analyze
Curators' Favorite Papers
The first paper, by A. Ahmed et al. in the journal Clinical Pharmacology and Therapeutics (Benefits of and Barriers to Pharmacogenomics-Guided Treatment for Major Depressive Disorder), discusses pharmacogenetic (PGx) testing in the context of depression. In a pilot study, 1,002 out of 1,013 (99%) subjects had an actionable
PharmGKB featured in Stanford Engineering Magazine
PharmGKB was the focus of Dr. Russ Altman’s talk at the 2018 Beckman Symposium held at Stanford in February and is now featured in the latest issue of the Stanford Engineering magazine.
Attendees at the symposium, which focused on technology, innovation and the human genome, were given a guided
CPIC Guideline Update: Carbamazepine, Oxcarbazepine and HLA genotype
The CPIC Guideline for carbamazepine, oxcarbazepine and HLA genotype is now published in Clinical Pharmacology and Therapeutics. The accepted article can be viewed on the PharmGKB pages for carbamazepine and oxcarbazepine and on the CPIC website.
Carbamazepine and oxcarbazepine are anticonvulsants which have been approved for treatment for epilepsy and,
Promote the study of Pharmacogenomics in the All of Us cohort
The NIH is collecting suggestions for what to study in a new large cohort of one million or more people living in the United States. The All of Us research program is part of the Precision Medicine Initiative and will recruit volunteers across the USA to share their data with
Curators' Favorite Papers
The first paper (Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned) describes the process of implementing systemwide thiopurine methyltransferase (TPMT) testing at the University of Florida Health Personalized Medicine Program (UF PMP). After the successful implementation of CYP2C19 testing for patients
New CPIC Guideline: CYP2D6 and tamoxifen
The CPIC Guideline for tamoxifen and CYP2D6 is now published in Clinical Pharmacology and Therapeutics. The accepted article can be viewed on the PharmGKB page for tamoxifen, and the CPIC website.
Tamoxifen is a selective estrogen receptor modulator (SERM) and is utilized in breast cancer treatment. Tamoxifen is extensively metabolized,
2018 Precision Medicine Conference
UF Precision Medicine Conference is focused on implementing PGx and genomic medicine, happening March 2018 in Orlando, Florida. See the website for registration and more information.
Curators' Favorite Papers
The first paper from Genetics in Medicine by Khoury et al. (From Public Health Genomics to Precision Public Health: a 20-Year Journey) reviews developments in the field of public health genomics over the last twenty years. Public health genomics deals with the “effective and responsible translation of genomic research into