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Caroline Thorn, Curator

PharmGKB and Reactome collaborate on two pathways

PharmGKB has collaborated with Reactome for two new pharmacokinetics pathways, Ribavirin, and Prednisone and Prednisolone available via both formats: Ribavirin Pathway, Pharmacokinetics on Reactome on PharmGKB Prednisone and Prednisolone Pathway, Pharmacokinetics on Reactomeon PharmGKB

Study of vitamin K pathways presents potential new warfarin candidates

Almost two decades after the cloning of VKORC1 and association with warfarin dose, a new pathway of vitamin K cycling has been published. Mishima et al [PMID:35922516] report on the Ferroptosis suppressor protein 1 (FSP1), coded for by the AIFM2 gene, and its mechanism of maintaining vitamin K in

Ask a Curator for Healthcare Professionals on June 7th

We are holding an Ask a Curator zoom targeted towards healthcare professionals wanting to learn more about PharmGKB and pharmacogenomics. This is part of NHGRI’s Healthcare Professionals Genomics Education Week (#MedGeneEd22). Be sure to spread the word to colleagues who may find this useful. We are asking people to

What does *1 really mean? And why does that matter?

A Haiku about PGx for National Poetry Month. Diagnosed star one, Yet severe toxicity. What did the lab test? What does *1 really mean? And why does that matter? The star alleles of the drug metabolizing enzyme genes are an unusual way of defining variation and are perhaps one of

"Ask a Curator" live zoom event

PharmGKB curators will hold a series of live Q&A events over Zoom to help people find and use different aspects of the knowledgebase. We hope this will be a great way to answer questions about PharmGKB and PGx which are specific to users’ individual needs or projects. These

Update to individual statin pathways to support release of new CPIC guidelines for statins

To coincide with the release of the updated CPIC guidelines for SLCO1B1, ABCG2 and CYP2C9 and statin-associated musculoskeletal symptoms, we have updated the statin pharmacokinetic (PK) pathways. We now have one PK pathway for each individual drug in the guideline and have added details of the specific metabolites as well

Pathways in progress, a way to accelerate the pathways visible to users

Thanks to user feedback regarding the PharmGKB pathways, we understand that many of our pathways are used for teaching and presentations, and that users love the detailed figures. We are also aware that many users are interested in the underlying data -- what's on the components tab, the

New PK pathways for drugs on the CPIC gene-drug pairs list

PharmGKB has curated new pathways for the pharmacokinetics of the following drugs that are on the CPIC gene-drug pairs list and either have existing guidelines or are slated for future consideration. Antidepressant: Trimipramine Inhaled anesthetics: Desflurane Enflurane Halothane Methoxyflurane Sevoflurane NSAIDs: Flurbiprofen Lornoxicam Meloxicam A complete list of PharmGKB pathways

Expanded Pharmacokinetics Pathways for PPIs

The Proton Pump Inhibitor Pathway, Pharmacokinetics has been updated and expanded to now highlight four pathways with candidate genes and drug metabolites involved for: Omeprazole and esomeprazole, Lanzoprazole and dexlansoprazole, Pantoprazole and Rabeprazole. The pathways illustrate the subtle differences between the metabolism of drugs in the class, their different sensitivities

Two new pathways released: Allopurinol Pharmacokinetics and Pimozide Pharmacokinetics.

Allopurinol is a purine analogue used in the treatment of gout. This drug has a level A CPIC Guideline for allopurinol and HLA-B. The new pathway shows the candidate genes and metabolites involved in Allopurinol Pharmacokinetics.Pimozide is a typical antipsychotic FDA approved for treatment of Tourette’s disorder. The