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PharmGKB Staff

How might genetic variants of a single gene affect addiction to cigarettes and response to anti-cancer therapy?

The human CYP2A6 enzyme is involved in the metabolism of many different compounds - including those found in our diet and therapeutic drugs. We have recently written an updated Very Important Pharmacogene (VIP) Summary that is published in Pharmacogenetics and Genomics. CYP2A6 has a major role in the metabolism of

Listen to an interview with the lead author of the CPIC HLA-B - abacavir dosing guideline

In this interview for The Aids Reader, Micheal Martin, PharmD, addresses why doctors may be reluctant to prescribe abacavir to HIV patients due to risk of hypersensitivity reactions, and explains how the genotype-based dosing guidelines recently published by CPIC can help guide therapy and avoid giving the drug to those

Text-Mining tool revalidated by the PharmGKB Curators

Keeping up with the ever-growing large volume of scientific articles published each day is a challenge, and there is a need for efficient text-mining tools that could support curation of this information. The PharmGKB Scientific Curators worked with informaticians at the Institute of Computational Linguistics in Switzerland to test and

PharmGKB featured on Stanford's Discovery Walk

The PharmGKB is included on the Stanford University Medical School 'Discovery Walk' monument, alongside major discoveries and achievements in the medical sciences over the last 150 years. On Bench panel 10_13 (located on the Discover Walk outside the Beckman Center), genomics and the post-genomics era are featured.

Watch the PGx educational video from St Jude's Children's Research Hospital

Protocol investigators and family members of patients from St Jude's Family Advisory Council discuss the PG4KDS pharmacogenetics implementation project in a video - we have added a link to the video on our website under the Outreach tab: "PGEN4Kids Study Information". In the video, Mary Relling

Clopidogrel: indication-specific pharmacogenetics

An article published in the May edition of Clinical Pharmacology & Therapeutics reviews the mixed results seen in different studies for the association between adverse cardiovascular events and the CYP2C19*2 allele in patients taking clopidogrel. The CYP2C19*2 allele confers loss of function of the CYP2C19 enzyme and thus

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There are several ways to view our blog: 1. Click on the rotating box images on our homepage - these link directly to the related blog post for each news item. 2. Click on our "News & Events" tab on the top blue bar on our website. Here

The PharmGKB Knowledge Pyramid

The PharmGKB Knowledge Pyramid (Figure 1) provides users with a visualization of the different types of information found in our knowledge base and, how this information is acquired and integrated together – from the accumulation of gene-drug knowledge at the bottom of the pyramid, to the implementation of pharmacogenomics in the

The Clinical Pharmacogenetics Implementation Consortium (CPIC)

The Clinical Pharmacogenetics Implementation Consortium (CPIC) was established in order to provide drug-dosing guidelines based on an individual’s genotype, if this genetic information is already available. These guidelines are published in Clinical Pharmacology and Therapeutics and summaries of the guidelines can be viewed in the PharmGKB on drug or

Data-driven prediction of drug effects and interactions

Tatonetti, et al. have recently published a database of off-label side effects (named OFFSIDES) and a database of drug-drug interactions (named TWOSIDES), both using data derived from the FDA Adverse Event Reporting Systems (AERS). Using these databases, and validating results in patient Electronic Medical Records, they found an increased risk