New CPIC Guideline: CYP3A5 and Tacrolimus
Guidelines regarding the use of pharmacogenetic tests for CYP3A5 in dosing tacrolimus have been published in Clinical Pharmacology and Therapeutics by the Clinical Pharmacogenetics Implementation Consortium (CPIC).
Tacrolimus is an immunosuppressive agent administered to transplant recipients to prevent and treat allograft rejection. Clinical use of tacrolimus is complicated by its