New PGRN Featured Project and PI for the Month of November
The PGRN website is featuring a new project and investigator of the month from the PAT (Pharmacogenomics of Arrhythmia Therapy) group.For detailed information, please visit the PGRN website.
More issues
From Genomics & Informatics to Precision Medicine
Several PharmGKB curators plan to attend UCSF's Institute for Human Genetics 2012 Symposium on Monday 5th Nov, entitled "From Genomics and Informatics to Precision Medicine".
Speakers include those from Genentech, Kaiser Permanente and prominent universities in the USA.
We hope to see you there!
PharmGKB team celebrates Halloween
The PharmGKB team joined the Halloween celebrations this week - take a look at our pumpkin carving skills!
ASHG Annual Meeting 2012 (6th-10th Nov)
The PharmGKB curators will be attending the American Society of Human Genetics Annual Meeting in San Francisco next week and look forward to a week of interesting talks and posters.
On Thursday 8th November (2:15-3:15pm) we will be presenting two posters - one focusing on the pharmacogenomic research
Defining our lists of PGx information
With the increasing implementation of pharmacogenomics knowledge we are often asked "What is the difference between the CPIC gene list, VIP list and the Clinical Annotations list on PharmGKB?"
Here we clarify their contents:
VIP genes (purple layer of the PharmGKB Knowledge Pyramid)
This is a list of
New pathway: Vemurafenib Pathway, Pharmacodynamics
We have added a new pathway: Vemurafenib PD pathway to our pathway collections.
Vemurafenib (marketed as ZELBORAF) is an oral BRAF inhibitor used to treat late-stage melanoma. It specifically targets the mutant BRAF protein (V600E isoform) that is found in approximately half of all cases of melanoma. Vemurafenib is a
PharmGKB welcomes Daniel Klein to the team
We are pleased to welcome curator Daniel Klein to the PharmGKB team. Daniel recently graduated from the University of California, San Diego. His background is physics (specializing in astrophysics) with minors in biology, chemistry, and psychology. During his senior year at UCSD, Daniel worked as a part-time curator for the
PGx Look Up Tables
The Translational Pharmacogenetics Project (TPP) is a PGRN-led initiative with the goal to operationalize the work of CPIC by translating widely accepted actionable pharmacogenetics discoveries into real-world clinical practice.
TPP creates "look up" tables by gene which contain phenotype and clinical decision support system information based on haplotypes
New Haplotype features on PharmGKB
New features on the Haplotype tab (example: CYP2A6):
* Details of the resources used to determine our curated haplotype maps and any important notes regarding the haplotypes are added by our curators.
* Previously we only displayed dbSNP rsIDs within haplotypes - now you can view other genetic variants that currently have
PharmGKB Clinical Annotations Update and New Levels of Evidence
We have launched an update of our Clinical Annotations, assessing new evidence available for each gene variant - drug association. Each Clinical Annotation is written by a PharmGKB curator and assigned a level of evidence. We have recently revised our criteria to provide 6 levels of evidence, from the highest