ClinPGx Blog (Page 49)

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Understanding the effect of protein structure variation on drug response

Understanding how genetic variants translate into variability in phenotype is important in the field of personalized medicine. In this review, Lahti et al discuss combining knowledge of pharmacogenetics, the impact of genetic variation on protein structure, and the molecular mechanisms of how a drug works (pharmacodynamics), to provide a greater

Review of Translational Bioinformatics

Russ Altman has published a review of translational bioinformatics based on his annual reviews at the 2012 Summit on Translational Bioinformatics (TBI) held by AMIA (American Medical Informatics Association). Read the article online at Clinical Pharmacology & Therapeutics.

How might genetic variants of a single gene affect addiction to cigarettes and response to anti-cancer therapy?

The human CYP2A6 enzyme is involved in the metabolism of many different compounds - including those found in our diet and therapeutic drugs. We have recently written an updated Very Important Pharmacogene (VIP) Summary that is published in Pharmacogenetics and Genomics. CYP2A6 has a major role in the metabolism of

New PGRN Featured Project and PI for the Month of May

The PGRN website is featuring a new project and investigator of the month from the PHONT (Pharmacogenomics Ontology Network Resource) group. Learn about the informatics efforts applied to pharmacogenomics and how this data is integrated into EMRs and its translation into clinical practice. For detailed information, please visit the PGRN

Listen to an interview with the lead author of the CPIC HLA-B - abacavir dosing guideline

In this interview for The Aids Reader, Micheal Martin, PharmD, addresses why doctors may be reluctant to prescribe abacavir to HIV patients due to risk of hypersensitivity reactions, and explains how the genotype-based dosing guidelines recently published by CPIC can help guide therapy and avoid giving the drug to those

Text-Mining tool revalidated by the PharmGKB Curators

Keeping up with the ever-growing large volume of scientific articles published each day is a challenge, and there is a need for efficient text-mining tools that could support curation of this information. The PharmGKB Scientific Curators worked with informaticians at the Institute of Computational Linguistics in Switzerland to test and

PharmGKB featured on Stanford's Discovery Walk

The PharmGKB is included on the Stanford University Medical School 'Discovery Walk' monument, alongside major discoveries and achievements in the medical sciences over the last 150 years. On Bench panel 10_13 (located on the Discover Walk outside the Beckman Center), genomics and the post-genomics era are featured.

Watch the PGx educational video from St Jude's Children's Research Hospital

Protocol investigators and family members of patients from St Jude's Family Advisory Council discuss the PG4KDS pharmacogenetics implementation project in a video - we have added a link to the video on our website under the Outreach tab: "PGEN4Kids Study Information". In the video, Mary Relling

Clopidogrel: indication-specific pharmacogenetics

An article published in the May edition of Clinical Pharmacology & Therapeutics reviews the mixed results seen in different studies for the association between adverse cardiovascular events and the CYP2C19*2 allele in patients taking clopidogrel. The CYP2C19*2 allele confers loss of function of the CYP2C19 enzyme and thus

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