CPIC

Six CPIC PGx-based dosing guidelines are now available on the National Guideline Clearinghouse website, a public resource for evidence-based clinical guidelines, an initiative of the Agency for Healthcare Research and Quality, US Department of Health Services. View the CPIC guidelines on the NGC website: * CYP2D6, CYP2C19 & tricyclic antidepressants * CYP2D6

The Clinical Pharmacogenomics Implementation Consortium (CPIC) has published guidelines for the use of genetic test results for HLA-B*15:02 and carbamazepine in Clinical Pharmacology and Therapeutics.  In cases where a patient is known to carry at least one HLA-B*15:02 allele, the guideline recommends that the clinician use

The 2013 update of the CPICguidelines for CYP2C19 and clopidogrel dosing is now available online, as an accepted article preview. This updated guideline refines the recommendations for specific CYP2C19alleles, with emphasis on the appropriate indication for CYP2C19genotype-directed antiplatelet therapy, and, an expanded literature review to include recent published evidence. Read

Guidelines regarding the use of pharmacogenomic tests in dosing for tricyclic antidepressants have been published in Clinical Pharmacology and Therapeutics.  The guideline focuses on amitriptyline and nortriptyline dosing for individuals with CYP2D6 and CYP2C19 haplotypes being treated for depression. Since most studies have examined the effects of CYP2D6 and CYP2C19

PharmGKB now has interactive PGx dosing guidelines...simply pick the genotype or diplotype of the gene from a dropdown menu and the CPIC recommended dosing guidelines for that specific allele combination will appear. These are available for all published CPIC guidelines. Simple instructions: 1. On PharmGKB, go to the drug

The 2013 update of the CPIC guidelines for TPMT and Thiopurine dosing is now available online, as an accepted article preview. CPIC genotype-based dosing guidelines are reviewed and updated every two years in order to be clinically current - this is the first update to be released. After an extensive

Allopurinol is an analog of the purine base hypoxanthine. It inhibits the conversion of hypoxanthine and xanthine to uric acid by XDH and is used in the treatment of gout. Severe cutaneous adverse reaction, SCAR, also known as allopurinol hypersensitivity syndrome, is a rare serious and sometimes fatal side effect

The American Society of Health-System Pharmacists (ASHP) has endorsed the CPIC guidelines for CYP2C19 genotype and clopidogrel therapy, published in Clinical Pharmacology and Therapeutics. In their report, they highlight that the guidelines address an important need for information on the clinical application of pharmacogenomic testing and appreciate that the recommendations

Statins are among the most commonly prescribed drugs in the world to treat hypercholesterolemia and prevent cardiovascular diseases. They effectively lower cholesterol levels by inhibiting the HMG-CoA reductase, the rate limiting enzyme involved in cholesterol formation. Though well tolerated in general, statins can lead to myopathy with symptoms ranging from

The Clinical Pharmacogenetics Implementation Consortium (CPIC) was established in order to provide drug-dosing guidelines based on an individual’s genotype, if this genetic information is already available. These guidelines are published in Clinical Pharmacology and Therapeutics and summaries of the guidelines can be viewed in the PharmGKB on drug or