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Latest — 09 Jul 2026

CPIC Comment on Pending DPYD Guideline Update

Although the updated CPIC guideline for DPYD and fluoropyrimidines is still in development, the authors have concluded, based on current evidence, that c.1129-5923C>G, the minor allele at rs75017182 and causal allele associated with the “HapB3” haplotype, will be assigned an allele value of 0.75. For

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Retiring the api.pharmgkb.org hostname

As part of our transition from PharmGKB to ClinPGx, we're retiring the old API hostname, api.pharmgkb.org, in favor of api.clinpgx.org. What's changing If your code, scripts, or integrations call the API at api.pharmgkb.org, you'll need to update them

Correction to CPIC Guideline for TPMT, NUDT15 and Thiopurines

A correction to Table 1 of the "Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update" was published in Clinical Pharmacology and Therapeutics. An individual carrying one no function allele plus one decreased function allele is an Intermediate Metabolizer (IM)

Updates to the CPIC Database and API

We want to inform everyone of some things that are changing (and some things that are not) in the CPIC database and API. CPIC and ClinPGx CPIC is now part of ClinPGx. The standalone CPIC site will retire soon, but all its content will move to ClinPGx. Visiting cpicpgx.org

CPIC is moving to the ClinPGx website

The Clinical Pharmacogenetics Implementation Consortium is moving to the ClinPGx website. All CPIC information will still be available in a similar format. All current and published CPIC URLs should re-direct to equivalent pages on the ClinPGx website, so existing bookmarks and links should not break. We plan for CPIC

New and Updated Antipsychotics Pathways

CPIC is currently evaluating evidence on antipsychotics and CYP2D6, CYP3A4 and CYP2C19 for the development of guidelines. To support this ClinPGx curators have expanded our set of antipsychotics pathways; updating and developing some of our in progress pathways and curating some new ones.

CPIC Guideline Update for TPMT, NUDT15 and Thiopurines

The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update has been published in Clinical Pharmacology and Therapeutics (PMID:41618934). The guideline contains multiple updates to the previous recommendations for adjusting the starting doses of azathioprine, mercaptopurine and thioguanine according to the

New PharmCAT release

Highlights of the latest releases (v3.1.0- v3.1.1) are: * CPIC function and phenotype assignments are used to provide genotype-level guidance from all sources including DPWG and FDA. For a detailed blog see, Genotype-Phenotype Mapping for Guideline and Drug Label Curation. * Allele definitions are up to

Genotype-Phenotype Mapping for Guideline and Drug Label Curation

ClinPGx now uses CPIC/ClinPGx allele function and phenotype mappings and terms for guideline and drug label curation, including the interactive genotype picker tools on DPWG guideline annotation pages. If a DPWG guideline gene is not a CPIC gene, then we will continue to use DPWG mappings based on documents

Updated FDA-approved label for Xeloda (capecitabine)

The FDA-approved label for Xeloda (capecitabine) was updated a week ago to include a boxed warning regarding adverse reactions in patients with complete DPD deficiency and to "Test patients for genetic variants of DPYD prior to initiating XELODA unless immediate treatment is necessary." This language is new.