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Latest — 14 Jul 2026

ClinPGx Drug Classification Survey

We would like to improve the drug categories that are used on the PharmDOG and the GSI results pages to group annotated drugs and are asking the user community to help us out by responding to our survey. Currently, drugs are grouped using the World Health Organization's Anatomical

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PharmCAT v3.4.0 Released

PharmCAT has a new release. This is an update to the recently announced PharmCAT 3.3.0 release that includes some minor bugfixes and a PharmVar update. Changelog Features * data: update from PharmVar for newly released CYP2C9 alleles (8ff5870) Bug Fixes * recommend bcftools 1.24 (adfef81) * reporter: fix bug when

PharmCAT v3.3.0 Released

We are excited to announce our latest release! This update is highly recommended. It fixes an issue with pharmcat_pipeline where it uses the original input VCF instead of the preprocessed VCF if it is given a directory instead of a file. Data highlights * PharmVar: new alleles were released for

CPIC Comment on Pending DPYD Guideline Update

Although the updated CPIC guideline for DPYD and fluoropyrimidines is still in development, the authors have concluded, based on current evidence, that c.1129-5923C>G, the minor allele at rs75017182 and causal allele associated with the “HapB3” haplotype, will be assigned an allele value of 0.75. For

Retiring the api.pharmgkb.org hostname

As part of our transition from PharmGKB to ClinPGx, we're retiring the old API hostname, api.pharmgkb.org, in favor of api.clinpgx.org. What's changing If your code, scripts, or integrations call the API at api.pharmgkb.org, you'll need to update them

Correction to CPIC Guideline for TPMT, NUDT15 and Thiopurines

A correction to Table 1 of the "Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update" was published in Clinical Pharmacology and Therapeutics. An individual carrying one no function allele plus one decreased function allele is an Intermediate Metabolizer (IM)

Updates to the CPIC Database and API

We want to inform everyone of some things that are changing (and some things that are not) in the CPIC database and API. CPIC and ClinPGx CPIC is now part of ClinPGx. The standalone CPIC site will retire soon, but all its content will move to ClinPGx. Visiting cpicpgx.org

CPIC is moving to the ClinPGx website

The Clinical Pharmacogenetics Implementation Consortium is moving to the ClinPGx website. All CPIC information will still be available in a similar format. All current and published CPIC URLs should re-direct to equivalent pages on the ClinPGx website, so existing bookmarks and links should not break. We plan for CPIC

New and Updated Antipsychotics Pathways

CPIC is currently evaluating evidence on antipsychotics and CYP2D6, CYP3A4 and CYP2C19 for the development of guidelines. To support this ClinPGx curators have expanded our set of antipsychotics pathways; updating and developing some of our in progress pathways and curating some new ones.

CPIC Guideline Update for TPMT, NUDT15 and Thiopurines

The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update has been published in Clinical Pharmacology and Therapeutics (PMID:41618934). The guideline contains multiple updates to the previous recommendations for adjusting the starting doses of azathioprine, mercaptopurine and thioguanine according to the