ClinPGx Blog (Page 39)

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CYP2C8 VIP published in PG&G

CYP2C8 is a member of the cytochrome P450 family of drug metabolizing enzymes. It plays a major role in the metabolism of many commonly used drugs. Several CYP2C8 SNPs have been associated with variability in metabolism, disposition and response for drugs such as repaglinide, rosiglitazone, pioglitazone, paclitaxel, bisphosphonates, amiodarone and

New PharmGKB VIP Summary: NAT2

N-acetyltransferase enzymes (NAT1 and NAT2) are involved in the metabolism and detoxification of xenobiotics. NAT2 is predominantly expressed in the liver and has a role in the metabolism of numerous therapeutic drugs including caffeine and BiDil. Genetic variants in the NAT2 gene result in a slow, intermediate or rapid acetylator

Tacrolimus and cyclosporine pathways published

Tacrolimus and cyclosporine are two immunosuppressants given to solid organ transplant patients to prevent allograft rejection. A PharmGKB summary discussing the pharmacokinetics, pharmacodynamics and pharmacogenetics of these two drugs has been published in Pharmacogenetics and Genomics, and is now available to read online ahead of print. The summary also includes

PharmGKB PGx summaries now available in the Genetic Testing Registry

The Genetic Testing Registry (GTR) now contains summaries written by PharmGKB Curators regarding the association between genes and drug responses that have CPIC therapeutic recommendations. These can be found on the GTR website under Conditions/Phenotypes and links to relevant clinical tests are provided on each page: * Warfarin response * Codeine

Visualizing Levels of Evidence

PharmGKB Clinical Annotations provide a summary of an association between a genetic variant and a drug response. Each is assigned a level of evidence by our curators, based on established criteria. We have created an illustration to help users understand the 4 levels of evidence:

CPIC guidelines now posted on guidelines.gov

Six CPIC PGx-based dosing guidelines are now available on the National Guideline Clearinghouse website, a public resource for evidence-based clinical guidelines, an initiative of the Agency for Healthcare Research and Quality, US Department of Health Services. View the CPIC guidelines on the NGC website: * CYP2D6, CYP2C19 & tricyclic antidepressants * CYP2D6

"Jack of all trades" drug pathway published

Methylene blue has many clinical uses including the treatment of methemoglobinemia and malaria, as a diagnostic dye and even has potential as a therapy for Alzheimer's disease. A PharmGKB summary combining the methylene blue pharmacodynamics pathway with the oxidative stress regulatory and pentose phosphate pathways in red blood

Personalized Prescriptions: Russ Altman's TEDx Talk

The mission of PharmGKB and the role of CPIC's therapeutic guidelines are nicely introduced in Russ's TEDxStanford talk, in which he uses the commonly prescribed drug codeine as an example to explain pharmacogenetics. 4 basic lessons are outlined: 1. People don't respond in the

New Pathway for Abacavir

We have posted a new pathway on PharmGKB summarizing the pharmacokinetics, pharmacodynamics and pharmacogenetics of abacavir. Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) pro-drug, used for treating human immunodeficiency virus (HIV) infection. Abacavir is converted through several enzymatic steps into its active form, carbovir 5’-triphosphate (CBV-TP), which works

Update to CYP2C19 TPP lookup table

We have verified that position rs3758581 in CYP2C19*1 is allele A. The CYP2C19 TPP lookup table has been updated accordingly. View CYP2C19 haplotypes.