ClinPGx Blog (Page 44)

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CPIC publishes guidelines on interpreting genetic test results for HLA-B*5801 when prescribing allopurinol therapy.

Allopurinol is an analog of the purine base hypoxanthine. It inhibits the conversion of hypoxanthine and xanthine to uric acid by XDH and is used in the treatment of gout. Severe cutaneous adverse reaction, SCAR, also known as allopurinol hypersensitivity syndrome, is a rare serious and sometimes fatal side effect

European Medicines Agency Drug Labels

European Public Assessment Reports (EPARs) for drugs published by the European Medicines Agency (EMA) that include pgx information are now available to view on PharmGKB. We add any pgx-containing EMA or FDA drug labels that come to our attention. Like our FDA drug label information, we provide a summary and

New PGRN Featured Project and PI for the Month of December

The PGRN website is featuring a new project and investigator of the month from the NWAP (Pharmacogenetics in Rural and Underserved Populations) group.For detailed information, please visit the PGRN website.

PharmGKB welcomes Julia Barbarino to the team

We are pleased to welcome scientific curator Julia Barbarino to the PharmGKB team. Julia recently completed her master's in Medical Molecular Genetics from the University of Aberdeen, Scotland, where her research focused on epigenetic modifications of the apolipoprotein E gene and their role in human longevity. While undertaking

New VIP gene summary for CYP2E1

A new VIP summary is available for CYP2E1, a member of the cytochrome P450 family of drug metabolizing enzymes. CYP2E1 is constitutively expressed in the liver but makes up less than 1% of the total hepatic P450 isoforms [Article: 20100563]. It metabolizes relatively few prescription drugs (approximately 2%), however its

PharmGKB welcomes Ugur Hodoglugil to the team

We are pleased to welcome scientific curator Ugur Hodoglugil to the PharmGKB team. Previously, Ugur has worked as research scientist on identifying the genetic determinants of complex traits (lipid and other metabolic phenotypes) and population structure at Gladstone Institutes, University of California San Francisco where he analyzed genome-wide scans data

New PGRN Featured Project and PI for the Month of November

The PGRN website is featuring a new project and investigator of the month from the PAT (Pharmacogenomics of Arrhythmia Therapy) group.For detailed information, please visit the PGRN website.

From Genomics & Informatics to Precision Medicine

Several PharmGKB curators plan to attend UCSF's Institute for Human Genetics 2012 Symposium on Monday 5th Nov, entitled "From Genomics and Informatics to Precision Medicine". Speakers include those from Genentech, Kaiser Permanente and prominent universities in the USA. We hope to see you there!

PharmGKB team celebrates Halloween

The PharmGKB team joined the Halloween celebrations this week - take a look at our pumpkin carving skills!

ASHG Annual Meeting 2012 (6th-10th Nov)

The PharmGKB curators will be attending the American Society of Human Genetics Annual Meeting in San Francisco next week and look forward to a week of interesting talks and posters. On Thursday 8th November (2:15-3:15pm) we will be presenting two posters - one focusing on the pharmacogenomic research