ClinPGx Blog (Page 37)

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To Replicate or Not to Replicate

Dr. Aslibekyan and colleagues propose that an alternative to replication of genetic association studies be considered in an article titled “To Replicate or Not to Replicate: The Case of Pharmacogenetic Studies” in Circulation: Cardiovascular Genetics(2013). It is understandable why replicating the positive results of a genetic association study is,

PharmGKB Unaffected by the Heartbleed Bug

The "Heartbleed Bug" has been in the news a lot lately, and for good reason. It's a security vulnerability in some versions of OpenSSL that allows the theft of information that is protected, under normal conditions, by the SSL/TLS encryption used to secure the Internet.

SLC22A1 VIP Summary Published in PG&G

Solute carrier family 22 (organic cation transporter), member 1 (SLC22A1, also called OCT1) is an important drug transporter mediating the hepatic uptake of many commonly used drugs. Several SLC22A1 variants have functional consequences and have been associated with altered disposition and response for drugs such as metformin, imatinib, sorafenib, tropisetron,

PharmGKB takes home Best Poster award at ISB 2014

PharmGKB is happy to announce that they were the recipients of the Best Poster award at the International Society for Biocuration conference in Toronto this week!

Russ Altman: Year In Review at AMIA Summit on Translational Bioinformatics 2014

Russ Altman presented the Year In Review yesterday at the AMIA Summit on Translational Bioinformatics 2014 in San Francisco. Dr. Altman's year in review is meant as an overview for trends and publications for the previous year and to speculate about what opportunities might lie in the year

Biocuration 2014 Toronto

PharmGKB Scientific Curators Ellen McDonagh and Julia Barbarino are attending the Biocuration 2014 conference in Toronto. On Monday 7th April, in a talk and poster presentation they will outline the PharmGKB curation process: how we curate PGx literature and interpret this for the clinic in the form of our Clinical

Dr. Michelle Whirl-Carrillo promoted to Associate Director of PharmGKB

PharmGKB is delighted to announce the promotion of Dr. Michelle Whirl-Carrillo to Associate Director. Dr. Whirl-Carrillo joined PharmGKB in 2002 as the project's first Scientific Curator. After briefly leaving PharmGKB to join the DTC genotyping start-up 23andMe, she returned in 2009 as the Assistant Director.

New PharmGKB VIP Summary: SLC22A1 (OCT1)

Solute carrier family 22 (organic cation transporter), member 1 (SLC22A1, also called OCT1) is a polyspecific cationic transporter mediating the uptake of many organic cations from the blood into epithelial cells. It is predominantly expressed in the liver and plays a critical role in the hepatic uptake of many commonly

Canadian pharmacogenomics group recommends genetic testing for patients prescribed carbamazepine

In a recent article published online in the journal Epilepsia, the Canadian Pharmacogenomics Network for Drug Safety (CPNDS) has recommended genetic testing for the alleles HLA-B*15:02 and HLA-A*31:01 in all carbamazepine-naive patients before initiation of treatment. In patients who test positive for either

American Society of Health-System Pharmacists to host live webinar on CPIC

The American Society of Health-System Pharmacists (ASHP) will be hosting a live webinar on Tuesday, April 15th from 2:00 - 3:00 pm EST discussing the Clinical Pharmacogenetics Implementation Consortium (CPIC). The webinar will be presented by Kelly E. Caudle, CPIC coordinator at St. Jude Children's Research