ClinPGx Blog (Page 42)

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Venlafaxine Pathway

Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) marketed for the treatment of depression disorders. The molecular targets of venlafaxine are the serotonin and norepinephrine transporters, resulting in inhibition of serotonin and noradrenaline reuptake from the synaptic cleft. A new pathway is posted on PharmGKB summarizing the metabolism of venlafaxine. Demethylation

Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics

We updated the Mycophenolic acid Pathway in collaboration with Kinjal Sanghavi and Dr. Vishal Lamba from the University of Minnesota.Mycophenolic Acid (MPA) is an immunosuppressive agent and is indicated as prophylactic agent in patients receiving allogeneic renal, cardiac or hepatic transplants. This PharmGKB pathway describes the steps and metabolites

GWAS in PGx: Pharmacogenomics Special Issue

This month's Future Medicine Pharmacogenomics Journal focuses on genome-wide association studies (GWAS) in PGx. Articles include highlights from the latest PGx GWAS, and topics covering data analysis techniques, rare variants, and direct-to-consumer PGx testing. Pharmacogenomics, March 2013, Volume 14, Number 4 Special Focus Issue: Genome-wide association studies in

Spanish Association of Hospital Pharmacists: Excellence Course in PGx

The current issue of the European Journal of Hospital Pharmacy has a report from our collaborators at Leiden University Medical Center regarding the Excellence Course in PGx organized by the Spanish Association of Hospital Pharmacists. The course was established to educate pharmacists on the concepts and clinical applications of PGx,

PharmGKB at AMIA Summit on Translational Bioinformatics

The American Medical Informatics Association (AMIA) Joint Summits on Translational Science is being held in San Francisco this week. Russ Altman is a keynote speaker at the conference, presenting a review of the past year in Translational Bioinformatics on Wednesday 20th March. Check out Michelle Whirl Carrillo's poster

CPIC publishes guidelines for tricyclic antidepressants and CYPs

Guidelines regarding the use of pharmacogenomic tests in dosing for tricyclic antidepressants have been published in Clinical Pharmacology and Therapeutics. The guideline focuses on amitriptyline and nortriptyline dosing for individuals with CYP2D6 and CYP2C19 haplotypes being treated for depression. Since most studies have examined the effects of CYP2D6 and CYP2C19

Interactive Dosing Guidelines now on PharmGKB

PharmGKB now has interactive PGx dosing guidelines...simply pick the genotype or diplotype of the gene from a dropdown menu and the CPIC recommended dosing guidelines for that specific allele combination will appear. These are available for all published CPIC guidelines. Simple instructions: 1. On PharmGKB, go to the drug

Data from Web Searches Could Help Identify Drug Side Effects and Drug-Drug Interactions

Researchers at Stanford and Columbia Universities teamed up with Microsoft to show that information from internet searches could potentially be used to identify novel drug-drug interactions and aid surveillance of drug safety. In 2011, Tatonetti et al utilized adverse drug event reporting system of the FDA to identify novel drug-drug

Considerations for automated functional comparisons

Congratulations on a great paper from Sean Mooney's lab and colleagues at the National Center for Biomedical Ontology at Stanford. It shows that when performing high throughput analysis of omics datasets such as microarrays, proteomics etc, combining manually curated GO terms with additional terms found by text mining

PharmGKB at the ASCPT 2013 Annual Meeting

The American Society for Clinical Pharmacology and Therapeutics (ASCPT) Annual Meeting is being held this week in Indianapolis. Michelle Whirl-Carrillo, Assistant Director of PharmGKB, will be presenting a talk entitled "PharmGKB: From Pharmacogenomics Knowledge to Clinical Interpretation and Implementation" in the "Putting Pharmacogenetics into Practice" symposium