ClinPGx Blog (Page 42)

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CPIC publishes guidelines for tricyclic antidepressants and CYPs

Guidelines regarding the use of pharmacogenomic tests in dosing for tricyclic antidepressants have been published in Clinical Pharmacology and Therapeutics. The guideline focuses on amitriptyline and nortriptyline dosing for individuals with CYP2D6 and CYP2C19 haplotypes being treated for depression. Since most studies have examined the effects of CYP2D6 and CYP2C19

Interactive Dosing Guidelines now on PharmGKB

PharmGKB now has interactive PGx dosing guidelines...simply pick the genotype or diplotype of the gene from a dropdown menu and the CPIC recommended dosing guidelines for that specific allele combination will appear. These are available for all published CPIC guidelines. Simple instructions: 1. On PharmGKB, go to the drug

Data from Web Searches Could Help Identify Drug Side Effects and Drug-Drug Interactions

Researchers at Stanford and Columbia Universities teamed up with Microsoft to show that information from internet searches could potentially be used to identify novel drug-drug interactions and aid surveillance of drug safety. In 2011, Tatonetti et al utilized adverse drug event reporting system of the FDA to identify novel drug-drug

Considerations for automated functional comparisons

Congratulations on a great paper from Sean Mooney's lab and colleagues at the National Center for Biomedical Ontology at Stanford. It shows that when performing high throughput analysis of omics datasets such as microarrays, proteomics etc, combining manually curated GO terms with additional terms found by text mining

PharmGKB at the ASCPT 2013 Annual Meeting

The American Society for Clinical Pharmacology and Therapeutics (ASCPT) Annual Meeting is being held this week in Indianapolis. Michelle Whirl-Carrillo, Assistant Director of PharmGKB, will be presenting a talk entitled "PharmGKB: From Pharmacogenomics Knowledge to Clinical Interpretation and Implementation" in the "Putting Pharmacogenetics into Practice" symposium

Curators' Favorite Papers

The current Curators' Favorite Papers' highlight an article describing a new method in identifying the genetic variation of gene expression using gene sets. To test their novel approach, Abo et al. used KEGG and PharmGKB pathways to define gene sets. In their method, SNPs and mRNA expression were

Congratulations, David Botstein!

We extend our hearty congratulations to Dr. David Botstein, winner of one of the initial Breakthrough Prizes in Life Sciences! Dr. Botstein, the former chairman of genetics at Stanford University, is now Professor of Genomics and molecular biology and Director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University.

FDA to post black box warning on codeine

The FDA has announced they will add a black box warning to the codeine drug label to contraindicate the use of the drug in children after tonsillectomy and/or adenoidectomy (see link). Codeine is a pro-drug that is converted to morphine, a reaction that occurs more efficiently in CYP2D6 ultra-rapid

TPMT allele nomenclature update published

Nomenclature for alleles of the Thiopurine Methyltransferase (TPMT) gene has been updated by the TPMT Nomenclature Committee and has been published online in Pharmacogenetics & Genomics. The committee have addressed issues such as previously existing duplication in star allele names, and has provided dbSNP rsIDs when available. View the updated

How does methylene blue work in the treatment of methemoglobinemia?

Methylene blue is a drug with many clinical applications, including treatment of infectious diseases such as malaria, a cyanide antidote, a dye for diagnostics, and even has the potential as a therapy for Alzheimer Disease and septic shock. It is indicated for the treatment of drug-induced methemoglobinemia - an increase