Check out the new features we have launched at www.pharmgkb.org * Information is now more readily available, including haplotypes listed in the PGx Research Tab on gene and drug pages, and sortable tables. * Our Clinical Annotations and Variant Annotations have their own page and a new look * Variant Annotations

RFA-HG-12-016 "Clinically relevant genetic variants resource:  a unified approach for identifying genetic variants for clinical use (U01)." The PharmGKB team is excited to see this RFA because clinical genomics has great potential to impact medicine. PharmGKB catalogs genetic variation of relevance to drug response (pharmacogenomics) and moves research

Though anti-TNF therapy can be effective in the treatment of many auto-immune diseases including Rheumatoid Arthritis (RA), drugs that block TNF can promote or exacerbate Multiple Sclerosis (MS). A genetic variant (rs1800693) within the TNFRSF1A gene has been identified in multiple GWAS as being associated with MS but not associated