ClinPGx Blog (Page 46)

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Curators' Favorite Papers

The current Curators' Favorite Papers highlight articles about the translation of pharmacogenomics into practice. The article by Johnson et al. describes the design of a customized pharmacogenetics genotyping array. This broad pharmacogenetics panel is built for the personalized medicine programs of the University of Florida and Stanford University [PMID:

New PGRN Featured Project and PI for the Month of September

The PGRN website is featuring a new project and investigator of the month from the PNAT (Pharmacogenomics of Nicotine Addiction Treatment) group.For detailed information, please visit the PGRN website.

The 1200 Patients Project

"The 1200 Patients Project" is a pharmacogenetics (PGx) implementation project established by a team at the University of Chicago who recruited 12 physicians to participate. The project is prospectively recruiting 1200 adults taking 1-6 prescription drugs, who are under the care of one of the participating physicians, and

Development of a Customized PGx Genotyping Array using key variants in PharmGKB

The University of Florida and Stanford University are undertaking a joint pharmacogenetics implementation project funded by the NIH, piloted first at Florida and replicated at Stanford. Initially, CYP2C19 genotype will be used to guide clopidogrel therapy, however a customized array of SNPs from 120 genes involved in drug response was

New sortable PGx Research tables on PharmGKB

Tables of our Variant Annotations found on the PGx Research tab (view on gene, drug, variant and haplotype pages) can now be sorted and filtered to allow you to see the most relevant information you want to see. example:If you want to see all variant annotations between the genetic

New features on the PharmGKB website

Check out the new features we have launched at www.pharmgkb.org * Information is now more readily available, including haplotypes listed in the PGx Research Tab on gene and drug pages, and sortable tables. * Our Clinical Annotations and Variant Annotations have their own page and a new look * Variant Annotations

Mining the pharmacogenomics literature

Briefings in Bioinformatics Special Issue: Current Progress in Bioinformatics 2012 contains an editorial by Russ Altman discussing the current status of bioinformatics research. Among the articles in this special issue is a review on the current status of techniques for mining of the pharmacogenomics literature and includes descriptions of studies

New PGRN Featured Project and PI for the Month of August

The PGRN website is featuring a new project and investigator of the month from the PARC (Pharmacogenomics and Risk of Cardiovascular Disease) group.For detailed information, please visit the PGRN website.

Curators' Favorite Papers

Current Curators' Favorite Papers: The review by Alfirevic and Pirmohamed discusses genetic factors associated with drug-induced liver injury with a special focus on HLA gene variation [PMID: 22850601]. Parvez et al. reports that a common SNP on chromosome 4q25, which is associated with atrial fibrillation, modulates response to antiarrhythmic

A message about RFA-HG-12-016

RFA-HG-12-016 "Clinically relevant genetic variants resource: a unified approach for identifying genetic variants for clinical use (U01)." The PharmGKB team is excited to see this RFA because clinical genomics has great potential to impact medicine. PharmGKB catalogs genetic variation of relevance to drug response (pharmacogenomics) and moves research